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Three type III secretion system (T3SS) inhibitors (compounds 5, 19, and 32) were identified by virtual screening and biological evaluation. These three compounds were evaluated against a panel of  Salmonella  species strains including  S. enteritidis ,  S. typhi ,  S. typhimurium ,  S. paratyphi , and  S. abortus equi , and their minimum inhibitory concentrations ranged from 1 to 53 μg/ml. Especially, these compounds showed comparable activity as the of the positive control gatifloxacin towards  S. abortus equi . The present results suggest that these new T3SS inhibitors could be used as a potential lead molecule for drug development of anti- Salmonella .

Identification of Novel Type Three Secretion System (T3SS) Inhibitors by Computational Methods and Anti-Salmonella Evaluations