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GABA is a major inhibitory neurotransmitter in the mammalian central nervous system (CNS). Inhibitory GABA A  channel circuits in the dorsal spinal cord are the gatekeepers of the nociceptive input from the periphery to the CNS. Weakening of these spinal inhibitory mechanisms is a hallmark of chronic pain. Yet, recent studies have suggested the existence of an earlier GABAergic “gate” within the peripheral sensory ganglia. In this study, we performed systematic investigation of plastic changes of the GABA-related proteins in the dorsal root ganglion (DRG) in the process of neuropathic pain development. We found that chronic constriction injury (CCI) induced general downregulation of most GABA A  channel subunits and the GABA-producing enzyme, glutamate decarboxylase, consistent with the weakening of the GABAergic inhibition at the periphery. Strikingly, the α5 GABA A  subunit was consistently upregulated. Knock-down of the α5 subunit  in vivo  moderately alleviated neuropathic hyperalgesia. Our findings suggest that while the development of neuropathic pain is generally accompanied by weakening of the peripheral GABAergic system, the α5 GABA A  subunit may have a unique pro-algesic role and, hence, might represent a new therapeutic target.

Neuropathic Injury–Induced Plasticity of GABAergic System in Peripheral Sensory Ganglia