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Widespread use of antimicrobial drugs has led to high levels of drug-resistance in pathogen populations and a need for novel sources of anti-bacterial and anti-parasitic compounds. Macroalgae (seaweed) are potentially a rich source of bioactive compounds, and several species have traditionally been used as vermifuges. Here, we investigated the anti-parasitic properties of four common cold-water Nordic seaweeds;  Palmaria palmata  (Rhodophyta),  Laminaria digitata ,  Saccharina latissima  and  Ascophyllum nodosum  (Ochrophyta, Phaeophyceae). Screening of organic extracts against helminths of swine ( Ascaris suum ) and sheep ( Teladorsagia circumcincta ) revealed that  S. latissima  and  L. digitata  had particularly high biological activity. A combination of molecular networking and bio-guided fractionation led to the isolation of six compounds from extracts of these two species identified in both fermented and non-fermented samples. The six isolated compounds were tentatively identified by using MS-FINDER as five fatty acids and one monoglyceride: Stearidonic acid ( 1 ), Eicosapentaenoic acid ( 2 ), Alpha-Linolenic acid ( 3 ), Docosahexaenoic acid ( 4 ), Arachidonic acid ( 5 ), and Monoacylglycerol (MG 20:5) ( 6 ). Individual compounds showed only modest activity against  A. suum , but a clear synergistic effect was apparent when selected compounds were tested in combination. Collectively, our data reveal that fatty acids may have a previously unappreciated role as natural anti-parasitic compounds, which suggests that seaweed products may represent a viable option for control of intestinal helminth infections.

Bio-Guided Fractionation and Molecular Networking Reveal Fatty Acids to Be Principal Anti-Parasitic Compounds in Nordic Seaweeds