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Aim  To investigate the variations and the frequencies of the  SLCO1B1  gene in the Thai population.    Methods  Collected samples were categorized into five regions of Thailand. DNA samples were genotyped for two variants, c.388A>G and c.521T>C of the  SLCO1B1,  using TaqMan ®  real-time PCR.    Results  The minor allele frequencies (MAFs) of two single nucleotide polymorphisms (SNPs) were not significantly different among the five regions. The most frequent haplotype was  SLCO1B1*1b  (frequency: 0.654), followed by  *1a  (frequency: 0.217),  *15  (frequency: 0.128), and  *5  (frequency: 0.001). We observed a similar frequency of OATP1B1 transporter phenotypes compared to other populations. 75.85% of the Thai subjects showed normal OATP1B1 activity, 22.5% showed intermediate OATP1B1 activity, and 1.58% showed low OATP1B1 activity.    Conclusion  This study reported the frequencies of the  SLCO1B1  variants and the subsequent OATP1B1 activity in a large cohort of Thais that can provide important information for the guidance of personalized drug therapy.

Genetic Variations and Frequencies of the Two Functional Single Nucleotide Polymorphisms of SLCO1B1 in the Thai Population