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Based on recent findings, an increased late sodium current (I Na,late ) plays an important pathophysiological role in cardiac diseases, including rhythm disorders. The article first describes what is I Na,late  and how it functions under physiological circumstances. Next, it shows the wide range of cellular mechanisms that can contribute to an increased I Na,late  in heart diseases, and also discusses how the upregulated I Na,late  can play a role in the generation of cardiac arrhythmias. The last part of the article is about I Na,late  inhibiting drugs as potential antiarrhythmic agents, based on experimental and preclinical data as well as in the light of clinical trials.

Late Sodium Current Inhibitors as Potential Antiarrhythmic Agents