English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Open

Presents the pdf analysis as premium feature

PDF Analysis

Insights

Presents the summarisation as premium feature

Summarisation

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Helicobacter pylori  is one of the most widespread infections involved in the pathogenesis of chronic gastritis, peptic ulcer, and gastric cancer. Hence, there is an urgent need to develop medications against  H. pylori . This study aimed to evaluate synergistic effect of  Rubus crataegifolius  (RF) and  Ulmus macrocarpa  Hance (UL) against  H. pylori . Antibacterial susceptibility of each extract either separately or in combination was studied against two  H. pylori  standard strains and 11 clinical isolates using agar dilution method. The effect of the extracts on  H. pylori  inoculated Balb/c mice model was also studied using single dosing (100 mg/kg each) approach. The MIC 50  of RF and UL were more than 100 and 200 µg/ml, respectively, against the tested strains. However, simultaneous treatment with RF and UL at 75 and 50 µg/ml, respectively, showed decreased viable cell number, MIC 70 , and at 75 µg/ml each showed synergic effect with MIC 90 . On  H. pylori  inoculated Balb/c mice model, RF and UL separately (100 mg/kg each) showed moderate anti- H. pylori  effect, while simultaneous treatment of RF and UL with same dose showed significant synergistic anti-gastric effects in stomach. The results showed a significant synergistic effect of plants extract against  H. pylori  infection and eventually gastric mucosal damage. Our finding could be considered a valuable support in the treatment of  H. pylori  induced gastritis and may contribute to the development of new and safe combined herbal product as anti- H. pylori  regimens.

Synergistic Effect of Rubus crataegifolius and Ulmus macrocarpa Against Helicobacter pylori Clinical Isolates and Gastritis