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An 11-year-old male patient with the deletion of  IKZF1  (Ikaros family zinc finger 1) and positive Breakpoint Cluster Region-C-Abelson oncogene 1( BCR-ABL1 ) acute lymphoblastic leukemia developed mucositis, gastrointestinal toxicity, hepatotoxicity, myelosuppression, and severe dermatologic toxicity during the first and second courses of high-dose methotrexate. The patient recovered completely after therapy. However, intracranial hemorrhage (ICH) occurred following oral methotrexate at a dose of 25 mg/m 2  in maintenance treatment, and he had neurological sequelae including hemiplegic paralysis.

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Intracranial Hemorrhage Following Oral Low-Dose Methotrexate After Multiple Toxicities Caused by High-Dose Methotrexate in Childhood Acute Lymphoblastic Leukemia