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Mosquitoes can transmit the terrible diseases to human beings. Soil-borne fungal products act as potential source for low-cost chemicals, used for developing eco-friendly control agents against mosquito-vector borne diseases. The prime aim of study was to check the larvicidal potential of fungus mycelia (by ethyl acetate solvent) extract from  Penicillium daleae  (KX387370) against  Culex quinquefasciatus  and  Aedes aegypti  and to test the toxicity of brine shrimp  Artemia nauplii , by observing the physiological activity. The ethyl acetate extract of  P. daleae  mycelia (after 15 days) from Potato dextrose broth (PDB) medium revealed better result with least LC 50  and LC 90  values of I-IV instars larvae of  Cx. quinquefasciatus  (LC 50  = 127.441, 129.087, 108.683, and 93.521; LC 90  = 152.758, 158.169, 139.091, and 125.918 μg/ml) and  Ae. aegypti  (LC 50  = 105.077, 83.943, 97.158, and 76.513; LC 90  = 128.035, 106.869, 125.640, and 104.606 μg/ml) respectively. At higher concentration (1000 μg/ml) of extracts, mortality begins at 18 h of exposure and attained 100% mortality after 48 h exposure. Overall, the activity was depends on the dose and time of exposure to the extracts. The stereomicroscopic and histopathological analysis of  Ae. aegypti  and  Cx. quinquefasciatus  larvae treated with mycelium ethyl acetate extract showed complete disintegration of abdominal region, particularly the midgut and caeca, loss of cuticular parts and caudal hairs. Morphological characterization of the fungi was performed and taxonomically identified through 5.8s rDNA technique. The phylogenetic analysis of rDNA sequence was carried out to find out the taxonomic and the evolutionary sketch of isolate in relation to earlier described genus  Penicillium . Behavior and swimming speed alteration was analyzed together with mortality. The results of the experiment indicates that swimming behavior recorder (SBR) is a appropriate tool to detect individual swimming speed of the  A. nauplii  organisms, since the values have been obtained in accordance with control monitored results showed the 2.75 mm s -1  and after 24 h treated found to be 0.72 mm s -1 , respectively. The extract-exposed to  A. nauplii  showed changes in body structures, i.e., intestine enlargement, eye formation, outer shell malformations and loss of antennae. In the present study, we aimed to investigate the toxicity of the ethyl acetate extract of  P. daleae  on  A. nauplii  larvae by performing the mortality, behavior and alterations in swimming responses. This is the first time report on the larvicidal efficacy of  P. daleae  ethyl acetate extract against  Cx. quinquefasciatus  and  Ae. aegypti  larvae.

frontiers in pharmacology

Larvicidal, Histopathological Efficacy of Penicillium daleae against Larvae of Culex quinquefasciatus and Aedes aegypti Plus Biotoxicity on Artemia nauplii a Non-target Aquatic Organism