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Background  Ovarian cancer (OC) is the most lethal gynecological malignancy worldwide. Increasing evidence indicates that TBC domain family is implicated in various cellular events contributing to initiation and development of different cancers, including OC. However, the role of TBC1D2, a crucial member of TBC domain family, remains unclear in OC.    Methods  IHC and qRT-PCR were employed to determine TBC1D2 expression in OC tissues and cells.  In vitro  and  in vivo  assays involving proliferation, migration, invasion were performed to explore the role of TBC1D2 in OC development. The underlying mechanism by which TBC1D2 promotes OC metastasis were elucidated using bioinformatics analysis, western blotting and co-immunoprecipitation.    Results  Upregulation of TBC1D2 was found in OC and was associated with a poor prognosis. Meanwhile, TBC1D2 promoted OC cell proliferation, migration, and invasion  in vitro  and facilitated tumor growth and metastasis  in vivo . Moreover, TBC1D2 contributed to OC cell invasion by E-cadherin degradation  via  disassembling Rac1-IQGAP1 complex. In addition, miR-373-3p was screened out and identified to inhibit OVCAR3 invasion  via  negative regulation of TBC1D2.    Conclusion  Our findings indicated that TBC1D2 is overexpressed in OC and contributes to tumor metastasis  via  E-cadherin degradation. This study suggests that TBC1D2 may be an underlying therapeutic target for OC.

TBC1D2 Promotes Ovarian Cancer Metastasis via Inducing E-Cadherin Degradation