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Glioma is the most common primary brain tumor that causes significant morbidity and mortality.  MAPK activated protein kinase 3  ( MAPKAPK3 / MK3 ) is a serine/threonine protein kinase regulating various cellular responses and gene expression. However, the role of  MK3  in tumor progress, prognosis, and immunity for glioma remains unclear. Here, we determined the expression and prognostic values of  MK3.  We further analyzed the correlation of  MK3  expression with immune infiltrations by using the biochemical methods and bioinformatic approaches with available databases. We find that  MK3  is aberrantly upregulated in glioma. In addition, the higher  MK3  expression is closely linked to the poor clinicopathologic features of glioma patients. Importantly,  MK3  expression is negatively correlated with the prognosis of patients with glioma. Mechanistically, we demonstrated that the correlated genes of  MK3  were mainly enriched in pathways that regulate tumor immune responses. The  MK3  level was significantly associated with tumor-infiltrating immune cells and positively correlated with the majority of tumor immunoinhibitors, chemokines, and chemokine receptors in glioma. Thus, these findings suggest the novel prognostic roles of  MK3  and define  MK3  as a promising target for glioma immunotherapy.

MAPK Activated Protein Kinase 3 Is a Prognostic-Related Biomarker and Associated With Immune Infiltrates in Glioma