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Objective  The purpose of the study is to explore the potential competing endogenous RNA (ceRNA) network and investigate the molecular mechanism of long noncoding RNA (lncRNA)  small nucleolar RNA host gene 1  ( SNHG1 ) in hepatocellular carcinoma (HCC) development.    Methods  By analyzing the data of HCC in The Cancer Genome Atlas (TCGA) database, we included differentially expressed lncRNA and microRNA (miRNA) profiles and constructed ceRNA networks related to the prognosis of HCC patients. qRT-PCR, Western blotting, 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), transwell assay, and the nude mouse model were employed to test the effects of  SNHG1  and  LMNB2  on tumor proliferation and growth  in vitro  and  in vivo .    Results  In the study, we identified 115 messenger RNAs (mRNAs), 12 lncRNAs, and 37 miRNAs by intersecting differentially expressed genes (DEGs) in TCGA and StarBase databases. Then,  SNHG1 – miR-326 – LMNB2  pathway came into notice after further survival analysis and hub gene screening. Our results showed that  SNHG1  expression was upregulated significantly in HCC tissues and cell lines. Downregulation of both  LMNB2 , the target of  miR-326  in HCC, and  SNHG1  inhibited tumor proliferation and growth  in vitro  and  in vivo . Furthermore,  SNHG1  could regulate  LMNB2  expression through binding to  miR-326  in HCC cell lines.    Conclusion   SNHG1  is a promising prognostic factor in HCC, and the  SNHG1 – miR-326 – LMNB2  axis may be a potential therapeutic target for HCC.

Long Noncoding RNA SNHG1 Regulates LMNB2 Expression by Sponging miR-326 and Promotes Cancer Growth in Hepatocellular Carcinoma