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Clear cell renal cell carcinoma (ccRCC) is characterized by the inactivation of the von Hippel–Lindau ( VHL ) gene. Of note, no other gene is mutated as frequently as  VHL  in ccRCC, turning out that patients with inactivated  VHL  constitute the majority of ccRCC-related character. Thus, differentially expressed genes (DEGs) and their molecular networks caused by  VHL  mutation were considered as important factors for influencing the prognosis of ccRCC. Here, we first screened out six DEGs ( GSTA1 ,  GSTA2 ,  NAT8 ,  FABP7 ,  SLC17A3 , and  SLC17A4 ) which downregulated in ccRCC patients with  VHL  non-mutation than with the mutation. Generally, most DEGs with high expression were associated with a favorable prognosis and low-risk score. Meanwhile, we spotted transcription factors and their kinases as hubs of DEGs. Finally, we clustered ccRCC patients into three subgroups according to the expression of hub proteins, and analyzed these subgroups with clinical profile, outcome, immune infiltration, and potential Immune checkpoint blockade (ICB) response. Herein, DEGs might be a promising biomarker panel for immunotherapy and prognosis in ccRCC. Moreover, the ccRCC subtype associated with high expression of hubs fit better for ICB therapy.

Differentially Expressed Genes in Clear Cell Renal Cell Carcinoma as a Potential Marker for Prognostic and Immune Signatures