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Background  Minichromosome maintenance ( MCM ) is known for participating in cell cycle progression, as well as DNA replication. While the diverse expression patterns and prognostic values of  MCM s in melanoma still remained unclear.    Methods  In the present study, the transcriptional and clinical profiles of  MCM s were explored in patients with melanoma from multiple databases, including GEO, TCGA, ONCOMINE, GEPIA, UALCAN, cBioPortal, and TIMER databases.    Results  We found that the elevated expressions of  MCM2–6  and  MCM10  were significantly expressed in melanoma compared to normal skin. High mRNA levels of  MCM4 ,  MCM5 , and  MCM10  were closely related to worse prognosis in patients with melanoma. GSEA showed hallmark pathways were most involved in mTORC1 signaling, G2M checkpoint, E2F targets, and mitotic spindle. Furthermore, we found potential correlations between the  MCM  expression and the immune cell infiltration, including B cells, CD4+ T cells, CD8+ T cells, neutrophils, macrophages, and dendritic cells.    Conclusion  Upregulated  MCM  gene expression in melanoma probably played a crucial part in the development and progression of melanoma. The upregulated  MCM4/5/10  expressions could be used as potential prognostic markers to improve the poor outcome and prognostic accuracy in patients with melanoma. Our study might shed light on the selection of prognostic biomarkers as well as the underlying molecular pathogenesis of melanoma.

Integrative Analysis of Minichromosome Maintenance Proteins and Their Prognostic Significance in Melanoma