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Casearlucin A, a diterpenoid obtained from  Casearia graveolens , has been reported to possess strong cytotoxic activity. However, the  in vivo  anti-tumor effects and the action mechanism of casearlucin A remain poorly understood. Our study revealed that casearlucin A arrested cell cycle at G0/G1 stage and induced cell apoptosis in cell level. Additionally, casearlucin A inhibited HepG2 cell migration  via  regulating a few of metastasis-related proteins. Furthermore, it inhibited tumor angiogenesis in zebrafish  in vivo . More importantly, casearlucin A significantly inhibited cell proliferation and migration in an  in vivo  zebrafish xenograft model. Collectively, these results are valuable for the further development and application of casearlucin A as an anticancer agent.

The Antitumor Activity and Mechanism of a Natural Diterpenoid From Casearia graveolens