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Purpose  We conducted a systematic literature search and pooled data from studies to compare the incidence of complications between the tumescent and non-tumescent techniques for mastectomy.    Methods  We searched PubMed, Embase, BioMed Central, Ovid, and CENTRAL databases for studies comparing the two mastectomy techniques up to November 1 st , 2020. We used a random-effects model to calculate odds ratios (OR) with 95% confidence intervals (CI).    Results  Nine studies were included with one randomized controlled trial (RCT). Meta-analysis indicated no statistically significant difference in the incidence of total skin necrosis (OR 1.18 95% CI 0.71, 1.98 I 2  = 82% p=0.52), major skin necrosis (OR 1.58 95% CI 0.69, 3.62 I 2  = 71% p=0.28), minor skin necrosis (OR 1.11 95% CI 0.43, 2.85 I 2  = 72% p=0.83), hematoma (OR 1.19 95% CI 0.80, 1.79 I 2  = 4% p=0.39), and infections (OR 0.87 95% CI 0.54, 1.40 I 2  = 54% p=0.56) between tumescent and non-tumescent groups. Analysis of studies using immediate alloplastic reconstruction revealed no statistically significant difference in the incidence of explantation between the two groups (OR 0.78 95% CI 0.46, 1.34 I 2  = 62% p=0.37). Multivariable-adjusted ORs on total skin necrosis were available from three studies. Pooled analysis indicated no statistically significant difference between tumescent and non-tumescent groups (OR 1.72 95% CI 0.72, 4.13 I 2  = 87% p=0.23).    Conclusion  Low-quality evidence derived mostly from non-randomized studies is indicative of no difference in the incidence of skin necrosis, hematoma, seroma, infection, and explantation between the tumescent and non-tumescent techniques of mastectomy. There is a need for high-quality RCTs to further strengthen the evidence.

Complication Differences Between the Tumescent and Non-Tumescent Dissection Techniques for Mastectomy: A Meta-Analysis