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Background  The purpose of this study was to investigate the correlation between  18 F-fluorodeoxyglucose (FDG) uptake and infiltrating immune cells in metastatic brain lesions.    Methods  This retrospective study included 34 patients with metastatic brain lesions who underwent brain  18 F-FDG positron emission tomography (PET)/computed tomography (CT) followed by surgery.  18 F-FDG uptake ratio was calculated by dividing the standardized uptake value (SUV) of the metastatic brain lesion by the contralateral normal white matter uptake value. We investigated the clinicopathological characteristics of the patients and analyzed the correlation between  18 F-FDG uptake and infiltration of various immune cells. In addition, we evaluated immune-expression levels of glucose transporter 1 (GLUT1), hexokinase 2 (HK2), and Ki-67 in metastatic brain lesions.    Results  The degree of  18 F-FDG uptake of metastatic brain lesions was not significantly correlated with clinical parameters. There was no significant relationship between the  18 F-FDG uptake and degree of immune cell infiltration in brain metastasis. Furthermore, other markers, such as GLUT1, HK2, and Ki-67, were not correlated with degree of  18 F-FDG uptake. In metastatic brain lesions that originated from breast cancer, a higher degree of  18 F-FDG uptake was observed in those with high expression of CD68.    Conclusions  In metastatic brain lesions, the degree of  18 F-FDG uptake was not significantly associated with infiltration of immune cells. The  18 F-FDG uptake of metastatic brain lesions from breast cancer, however, might be associated with macrophage activity.

Correlation Between 18F-FDG Uptake and Immune Cell Infiltration in Metastatic Brain Lesions