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Long non-coding RNAs (lncRNAs) are reported to participate in tumor development. It has been manifested in previous researches that lncRNA  ELFN1-AS1  is involved in early-stage colon adenocarcinoma with potential diagnostic value. However, no studies have revealed the specific mechanism of  ELFN1-AS1  in colon cancer, and there are no other studies on whether  ELFN1-AS1  is associated with tumorigenesis. In our study,  ELFN1-AS1  with high expression in colon cancer was selected by TCGA analysis, and the survival analysis was carried out to verify it. Subsequently, qRT-PCR was adopted for validating the results in tissues and cell lines. Cell counting kit-8 (CCK8), 5-ethynyl-2’-deoxyuridine (EdU), cell colon, cell apoptosis, cell cycle, cell migration, and invasion assays were utilized to assess the role of  ELFN1-AS1  in colon cancer. Results uncovered that  ELFN1-AS1  expression was prominently raised in colon cancer cells and tissues.  ELFN1-AS1  decrement restrained cells to grow through interfering with distribution of cell cycle and promoting apoptosis. Meanwhile,  ELFN1-AS1  decrement weakened the capacity of cells to migrate and invade. What’s more,  ELFN1-AS1  was uncovered to act as a competing endogenous RNA (ceRNA) to decrease miR-191-5p expression, thus raising  special AT-rich sequence-binding protein 1  ( SATB1 ), a downstream target of ceRNA. To sum up,  ELFN1-AS1  drives colon cancer cells to proliferate and invade through adjusting the miR-191-5p/ SATB1  axis. The above results disclose that lncRNA  ELFN1-AS1  is possibly a novel treatment target for colon cancer cases.

frontiers in oncology

RETRACTED: Long Non-Coding RNA ELFN1-AS1 Promoted Colon Cancer Cell Growth and Migration via the miR-191-5p/Special AT-Rich Sequence-Binding Protein 1 Axis