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Background:  The management of ground glass nodules (GGNs) remains a distinctive challenge. This study is aimed at comparing the predictive growth trends of radiomic features against current clinical features for the evaluation of GGNs.   Methods:  A total of 110 GGNs in 85 patients were included in this retrospective study, in which follow up occurred over a span ≥2 years. A total of 396 radiomic features were manually segmented by radiologists and quantitatively analyzed using an Analysis Kit software. After feature selection, three models were developed to predict the growth of GGNs. The performance of all three models was evaluated by a receiver operating characteristic (ROC) curve. The best performing model was also assessed by calibration and clinical utility.   Results:  After using a stepwise multivariate logistic regression analysis and dimensionality reduction, the diameter and five specific radiomic features were included in the clinical model and the radiomic model. The rad-score [odds ratio (OR) = 5.130;  P  < 0.01] and diameter (OR = 1.087;  P  < 0.05) were both considered as predictive indicators for the growth of GGNs. Meanwhile, the area under the ROC curve of the combined model reached 0.801. The high degree of fitting and favorable clinical utility was detected using the calibration curve with the Hosmer-Lemeshow test and the decision curve analysis was utilized for the nomogram.   Conclusions:  A combined model using the current clinical features alongside the radiomic features can serve as a powerful tool to assist clinicians in guiding the management of GGNs.

The Growth Trend Predictions in Pulmonary Ground Glass Nodules Based on Radiomic CT Features