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Kidney renal clear cell carcinoma (KIRC) and kidney renal papillary cell carcinoma (KIRP) are the most common RCC types. RCC has high immune infiltration levels, and immunotherapy is currently one of the most promising treatments for RCC. Collagen triple helix repeat containing 1 (CTHRC1) is an extracellular matrix protein that regulates tumor invasion and modulates the tumor microenvironment. However, the association of  CTHRC1  with the prognosis and tumor-infiltrating lymphocytes of KIRP and KIRC has not been reported. We examined the  CTHRC1  expression differences in multiple tumor tissues and normal tissues  via  exploring TIMER, Oncomine, and UALCAN databases. Then, we searched the Kaplan-Meier plotter database to evaluate the correlation of  CTHRC1  mRNA level with clinical outcomes. Subsequently, the TIMER platform and TISIDB website were chosen to assess the correlation of  CTHRC1  with tumor immune cell infiltration level. We further explored the causes of aberrant  CTHRC1  expression in tumorigenesis. We found that  CTHRC1  level was significantly elevated in KIRP and KIRC tissues relative to normal tissues.  CTHRC1  expression associates with tumor stage, histology, lymph node metastasis, and poor clinical prognosis in KIRP. The  CTHRC1  level correlates to tumor grade, stage, nodal metastasis, and worse survival prognosis. Additionally,  CTHRC1  is positively related to different tumor-infiltrating immune cells in KIRP and KIRC. Moreover,  CTHRC1  was closely correlated with the gene markers of diverse immune cells. Also, high  CTHRC1  expression predicted a worse prognosis in KIRP and KIRC based on immune cells. Copy number variations (CNV) and DNA methylation might contribute to the abnormal upregulation of  CTHRC1  in KIRP and KIRC. In conclusion,  CTHRC1  can serve as a biomarker to predict the prognosis and immune infiltration in KIRP and KIRC.

CTHRC1 Is a Prognostic Biomarker and Correlated With Immune Infiltrates in Kidney Renal Papillary Cell Carcinoma and Kidney Renal Clear Cell Carcinoma