English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background:  Adenylyl cyclase type 9 ( ADCY9 ) modulates signal transduction by producing the second messenger cyclic AMP. It has been reported that  ADCY9  gene polymorphisms were associated with cancer development. The aim of this study was to investigate whether  ADCY9  gene polymorphisms could contribute to the susceptibility of hepatocellular carcinoma (HCC) in the Chinese Han population.   Methods:  In the present study, five single-nucleotide polymorphisms (SNPs) in  ADCY9  were genotyped using Agena MassARRAY platform in 876 subjects from China. Logistic regression was used to assess the effects of SNPs on HCC risk. Associations were also evaluated for HCC risk stratified by age and gender. False discovery rate (FDR) was used to correct multiple testing.   Results:  After adjusting for age and gender, we found a significant relationship between heterozygous genotypes of rs2531995 and HCC risk (OR = 1.34, 95% CI = 1.01–1.77,  p  = 0.045).  ADCY9  rs2230742 had a strong relationship with lower risk of HCC in allele ( p  = 0.006), co-dominant ( p  = 0.023), dominant ( p  = 0.010), and additive ( p  = 0.006) models. Stratified analysis showed that rs879620 increased HCC risk and rs2230742 was associated with lower risk of HCC in the individuals aged 55 or younger, rs2531992 significantly decreased HCC risk in the elder group (age > 55). For women, rs2230742 and rs2230741 were significantly associated with HCC risk in multiple models ( p  < 0.05). FDR analysis showed that rs2230742 could protect individuals from HCC risk in the allele model (FDR -p  = 0.030). In addition, haplotype analysis indicated that C rs879620 A rs2230742 A rs2230741  haplotype was a protective factor for HCC (OR = 0.67, 95% CI = 0.50–0.89,  p  = 0.007, FDR -p  = 0.028).   Conclusion:  Our findings suggest that  ADCY9  gene polymorphisms are associated with HCC risk in the Chinese Han population.

A Case–Control Study of ADCY9 Gene Polymorphisms and the Risk of Hepatocellular Carcinoma in the Chinese Han Population