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Objective:  To explore the difference of perfusion parameters between gastric cancer (GC) and gastric stromal tumors (GSTs) by using oral contrast plus contrast-enhanced ultrasonography (OC+CEUS).   Methods:  We retrospectively reviewed 149 patients with histologically confirmed gastric lesions (80 patients with GC and 69 patients with GST). OC+CEUS was performed in all patients in the GC group and the GST group before surgery. The cine loops of OC+CEUS of all cases were analyzed. The perfusion parameters including arrival time (AT), time to peak (TTP), basal intensity (BI), and peak intensity (PI) were obtained via a program designed for autotracking contrast quantification (ACQ). The between-group differences in these parameters were compared.   Results:  According to time-intensity curve (TIC) analysis, high-risk GST had higher PI than low-risk GST ( P  < 0.05). GC had faster AT and higher PI than normal gastric wall ( P  < 0.05); GST had higher PI than normal gastric wall ( P  < 0.05). Furthermore, the GC group had faster AT and higher PI than the GST group ( P  < 0.05). In contrast, the difference in BI and peak time (TTP) between the groups was not significant ( P  > 0.05).   Conclusion:  AT and PI differ significantly between the GC group and the GST group. As a new method, OC+CEUS has value for the differential diagnosis of GC and GST.

frontiers in oncology

Difference in Perfusion Parameters Between Gastric Cancer and Gastric Stromal Tumors: Evaluation With Oral Contrast Plus Contrast-Enhanced Ultrasonography