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Objectives:  To assess the imaging biomarkers of glucose metabolic activity and diffusion-weighted imaging (DWI) derived from pretreatment integrated  18 F-fluorodeoxyglucose positron emission tomography-magnetic resonance ( 18 F-FDG PET/MR) imaging as potential predictive factors of metastasis in patients with pancreatic ductal adenocarcinoma (PDAC).   Patients and Methods:  We retrospectively included 17 consecutive patients with pathologically confirmed PDAC by pretreatment  18 F-FDG PET/MR. The study subjects were divided into a non-metastatic group (M0, six cases) and a metastatic group (M1, 11 cases). The  18 F-FDG PET/MR images were reviewed independently by two board certificated nuclear medicine physicians and one radiologist. Conventional characteristics and quantitative parameters from both PET and apparent diffusion coefficient (ADC) were assessed. The texture features were extracted from LIFEx packages ( www.lifexsoft.org ), and a 3D tumor volume of interest was manually drawn on fused PET/ADC images. Chi-square tests, independent-samples  t -tests and Mann–Whitney  U -tests were used to compare the differences in single parameters between the two groups. A logistic regression analysis was performed to determine independent predictors. A receiver operating characteristic (ROC) curve analysis was performed to assess the discriminatory power of the selected parameters. Correlations between metabolic parameters and ADC features were calculated with Spearman's rank correlation coefficient test.   Results:  For conventional parameters, univariable analysis demonstrated that the M1 group had a significantly larger size and a higher peak of standardized uptake value (SUV peak ), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) than those of the M0 group ( p  < 0.05 for all). TLG remained significant predictor in the multivariable analysis, but there were no significant differences for the area under the ROC curve (AUC) among the four conventional features in differential diagnoses ( p  > 0.05 for all). For the texture features, there were four features from the PET image and 13 from the ADC map that showed significant differences between the two groups. Multivariate analysis indicated that one feature from PET and three from the ADC were significant predictors. TLG was associated with ADC-GLRLM_GLNU ( r  = 0.659), ADC-GLRLM_LRHGE ( r  = 0.762), and PET-GLRLM_LRHGE ( r  = 0.806).   Conclusions:  Multiple parameters and texture features of primary tumors from  18 F-FDG PET/MR images maybe reliable biomarkers to predict synchronous metastatic disease for the pretreatment PDAC.

frontiers in oncology

Performance of Multiparametric Functional Imaging and Texture Analysis in Predicting Synchronous Metastatic Disease in Pancreatic Ductal Adenocarcinoma Patients by Hybrid PET/MR: Initial Experience