English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Background:  Nasopharyngeal carcinoma (NPC) is a malignant nasopharyngeal disease with a complicated etiology that occurs mostly in southern China. Intestinal flora imbalance is believed to be associated with a variety of organ malignancies. Current studies revealed that the destruction of intestinal flora is associated with NPC, and many studies have shown that intestinal flora can be used as a biomarker for many cancers and to predict cancer.   Methods:  To compare the differences in intestinal flora compositions and biological functions among 8 patients with familial NPC (NPC_F), 24 patients with sporadic NPC (NPC_S), and 27 healthy controls (NOR), we compared the intestinal flora DNA sequencing and hematological testing results between every two groups using bioinformatic methods.   Results:  Compared to the NOR group, the intestinal flora structures of the patients in the NPC_F and NPC_S groups showed significant changes. In NPC_F,  Clostridium ramosum, Citrobacter  spp.,  Veillonella  spp., and  Prevotella  spp. were significantly increased, and  Akkermansia muciniphila  and  Roseburia  spp. were significantly reduced. In NPC_S,  C. ramosum, Veillonella parvula, Veillonella dispar , and  Klebsiella  spp. were significantly increased, and  Bifidobacterium adolescentis  was significantly reduced. A beta diversity analysis showed significant difference compared NPC_F with NOR based on Bray Curtis ( P  = 0.012) and Unweighted UniFrac ( P  = 0.0045) index, respectively. The areas under the ROC curves plotted were all 1. Additionally, the concentrations of 5-hydroxytryptamine (5-HT) in NPC_F and NPC_S were significantly higher than those of NOR.  C. ramosum  was positively correlated with 5-HT (rcm: 0.85,  P  < 0.001). A functional analysis of the intestinal flora showed that NPC_F was associated with Neurodegenerative Diseases ( P  = 0.023) and that NPC_S was associated with Neurodegenerative Diseases ( P  = 0.045) as well.   Conclusion:  We found that NPC was associated with structural imbalances in the intestinal flora, with  C. ramosum  that promoted the elevation of 5-HT and opportunistic pathogens being significantly increased, while probiotics significantly decreased.  C. ramosum  can be used as a novel biomarker and disease prediction models should be established for NPC. The new biomarkers and disease prediction models may be used for disease risk prediction and the screening of high-risk populations, as well as for the early noninvasive diagnosis of NPC.

Intestinal Flora Disruption and Novel Biomarkers Associated With Nasopharyngeal Carcinoma