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Objectives:  Computed tomography (CT) is an important technique for evaluating the condition and prognosis of patients with thymomas, and it provides guidance regarding treatment strategies. However, the correlation between CT imaging features, described using standard report terms, and clinical characteristics, Masaoka–Koga stages, and World Health Organization (WHO) classifications of patients with thymomas has not been described in detail nor has risk factor analysis been conducted.   Methods:  Overall, 159 patients with thymomas who underwent preoperative contrast-enhanced CT between September 2011 and December 2018 were retrospectively reviewed. We assessed the clinical information, CT imaging features, and pathological findings for each patient. A total of 89 patients were specially used to evaluate postoperative recurrence or metastasis between September 2011 and December 2015 to obtain an appropriate observation period. The relationship between CT imaging features and clinical characteristics, Masaoka–Koga stage, and WHO histological classification were analyzed, and related risk factors based on CT imaging features were identified.   Results:  CT imaging features did not significantly differ based on sex or age. Some imaging features demonstrated significant differences between the groups with and without related clinical characteristics. Contour (odds ratio [OR] = 3.711,  P  = 0.005), abutment ≥50% (OR = 4.277,  P  = 0.02), and adjacent lung abnormalities (OR = 3.916  P  = 0.031) were independent risk factors for relapse or metastasis. Among all imaging features, there were significant differences between stage I/II and III/IV lesions in tumor size, calcification, infiltration of surrounding fat, vascular invasion, pleural nodules, elevated hemidiaphragm, and pulmonary nodules. Tumor size (odds ratio = 1.261,  P  = 0.014), vascular invasion (OR = 2.526,  P  = 0.023), pleural nodules (OR = 2.22,  P  = 0.048), and pulmonary nodules (OR = 3.106,  P  = 0.006) were identified as independent risk factors. Tumor size, contour, internal density, infiltration of surrounding fat, and pleural effusion significantly differed between low- and high-risk thymomas. Tumor size (OR = 1.183,  P  = 0.048), contour (OR = 2.288,  P  = 0.003), internal density (OR = 2.192,  P  = 0.024), and infiltration of surrounding fat (OR = 2.811  P  = 0.005) were independent risk factors.   Conclusions:  Some CT imaging features demonstrated significant correlations with clinical characteristics, Masaoka–Koga clinical stages, and WHO histological classifications in patients with thymomas. Familiarity with CT features identified as independent risk factors for these related clinical characteristics can facilitate preoperative evaluation and treatment management for the patients with thymoma.

frontiers in oncology

Relationship Between Computed Tomography Imaging Features and Clinical Characteristics, Masaoka–Koga Stages, and World Health Organization Histological Classifications of Thymoma