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Prostate cancer (PC) remains the second-most frequently diagnosed cancer among men worldwide and the fifth leading cause of cancer deaths (1). Despite great efforts to optimize radiotherapy, androgen deprivation, and chemotherapy, no curative treatment exists for advanced PC to date. This is due to the fact that during tumor progression and treatment, many changes occur in signaling pathways that lead to therapy resistance and treatment failure (2). Therefore, the search has to concentrate on signaling pathways that can be influenced even in advanced stages.

Tumor-Specific Induction of the Intrinsic Apoptotic Pathway—A New Therapeutic Option for Advanced Prostate Cancer?