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The impact of fat intake on health has become a growing public concern. The existing evidence linking specific dietary fat intake with mortality is controversial. We aimed to investigate the association between fat intake and total and cause-specific mortality in the Prostate, Lung, Colorectal, and Ovarian (PLCO) cancer screening trial. Intakes of saturated fatty acids (SFAs), trans-fatty acids (TFAs), monounsaturated fatty acids (MUFAs), and polyunsaturated fatty acids (PUFAs) were assessed  via  food frequency questionnaires. The primary outcomes were total, cardiovascular disease (CVD), and cancer mortality. Multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox regression model adjusting for confounders. Overall, 24,141 deaths were recorded over a total 1,672,715 person-years of follow-up. There was a significant positive association between SFA consumption and total mortality (HR  Q 5  vs .  Q 1  = 1.13, 95% CI 1.05–1.22;  P  for trend  < 0.001). PUFA intake was strongly inversely associated with total mortality (HR  Q 5  vs .  Q 1  = 0.79, 95% CI 0.73–0.85;  P  for trend  < 0.001) and CVD mortality (HR  Q 5  vs .  Q 1  = 0.66, 95% CI 0.58–0.75;  P  for trend  < 0.001). There was a similar, but to a lesser extent, association between MUFA intake and total and CVD mortality [HR  Q 5  vs .  Q 1  0.91 (95% CI: 0.84–0.99),  P  for trend  = 0.044 and 0.85 (0.73–0.98),  P  for trend  = 0.020, respectively]. None of these types of dietary fat were associated with cancer mortality (all  P  for trend  > 0.05). In conclusion, this study observed a detrimental effect of SFA intake on total mortality; in contrast, greater consumption of PUFAs and MUFAs were associated with lower risks of all-cause death and CVD mortality.

Associations of Dietary Fat Intake With Mortality From All Causes, Cardiovascular Disease, and Cancer: A Prospective Study