English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Gut microbiota has a strong influence on the onset and development of systemic lupus erythematosus (SLE), and several studies have demonstrated the effectiveness of microbiota-derived butyrate to ameliorate SLE. However, the roles of butyrate on gut microbiota in SLE are not understood. Using MRL/lpr lupus-prone mice, we examined gut microbiota profiles after butyrate treatment by 16S rRNA sequencing. Alterations in intestinal microbiome in mice with lupus-like disease were mainly characterized by a reduction in microbial diversity, with an increased abundance of Bacteroidetes and a decrease of Firmicutes. Treatment of lupus-prone mice with butyrate resulted in increased abundance of Firmicutes ( P  = 0.003), Clostridia ( P  = 0.005), Clostridiales ( P  = 0.005),  Lachnospiraceae  ( P  = 0.009),  Ruminococcaceae  ( P  = 0.021),  Peptostreptococcaceae  ( P  = 0.021),  Ruminiclostridium  ( P  = 0.016),  Oscillibacter  ( P  = 0.048),  Romboutsia  ( P  = 0.025),  Lachnoclostridium  ( P  = 0.012),  Coprococcus  ( P  = 0.015),  Ruminococcus  ( P  = 0.011),  Clostridium leptum  ( P  < 0.05), and  Dorea_spp . ( P  = 0.019), and a reduced proportion of Bacteroidetes ( P  = 0.004), Bacteroidia ( P  = 0.004), and Bacteroidales ( P  = 0.004). Further, butyrate supplementation could ameliorate kidney damage. Overall, this study suggests that gut microbiota alterations occur in MRL/lpr lupus-prone mice following treatment with butyrate. Butyrate supplementation ameliorated gut microbiota dysbiosis. These findings support the use of butyrate and butyrate-producing bacteria as potential treatments for SLE.

Sodium Butyrate Ameliorates Gut Microbiota Dysbiosis in Lupus-Like Mice