English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Parallel fiber (PF) synapses show pronounced and lasting facilitation during bursts of high-frequency activity. They typically connect to their target neurons  via  a single active zone (AZ), harboring few release sites (~2–8) with moderate initial vesicular release probability (~0.2–0.4). In light of these biophysical characteristics, it seems surprising that PF synapses can sustain facilitation during high-frequency periods of tens of action potentials (APs). Recent findings suggest an increase in the number of occupied release sites due to ultra-rapid (~180 s −1 ), Ca 2+  dependent recruitment of synaptic vesicles (SVs) from replenishment sites as major presynaptic mechanism of this lasting facilitation. On the molecular level, Synaptotagmin 7 or Munc13s have been suggested to be involved in mediating facilitation at PF synapses. The recruitment of SVs from replenishment sites appears to be reversible on a slower time-scale, thereby, explaining that PF synapses rapidly depress and ultimately become silent during low-frequency activity. Hence, PF synapses show high-frequency facilitation (HFF) but low-frequency depression (LFD). This behavior is explained by regulation of the number of occupied release sites at the AZ by AP frequency.

Control of Presynaptic Parallel Fiber Efficacy by Activity-Dependent Regulation of the Number of Occupied Release Sites