English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

It has been claimed over the years—most recently in this journal and several others—that neuronal degeneration in adult brain arising during chronic alcohol exposure is, or is likely to be, via “excitotoxicity” (Chandrasekar, 2013; Mehta et al., 2013; Crews and Vetreno, 2014). A purpose of this opinion piece is to reinforce a view, noted earlier (Collins and Neafsey, 2012), that an excitotoxic mechanism underlying alcoholic neurodamage in the mature brain has never been experimentally proven in vivo. Indeed, pharmacological results in neuronal degeneration studies with repetitively intoxicated (binged) adult rats indicate that the excitotoxic route is insignificant—more about this later.

Alcohol, Excitotoxicity and Adult Brain Damage: An Experimentally Unproven Chain-of-Events