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Substance dependence is characterized by compulsive substance seeking and high vulnerability to relapse. A major challenge in current substance addiction research is not only to understand the immediate effects of substances of abuse on brain operations. It is also to define, at the behavioral and neural levels, how cognitive, emotional, and motivational processes interact with substance use in order to lead to this psychopathological state which defines addiction. For the last decade, research and progress into the biological basis of the addictive process has led to a rapidly growing number of pharmacological agents used to interrupt the progress of the addiction pattern, however without a significant/adequate impact.

Modulation of Mood States as a Major Factor in Relapse to Substance Use