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“Chronic” periodontitis and its keystone pathogen  Porphyromonas gingivalis  have repeatedly been associated with Alzheimer’s disease (AD). Pathological hallmarks in AD are brain accumulations of amyloid-beta and neurofibrillary tangles consisting of aggregated and hyperphosphorylated tau. In addition, neuroinflammation induced by  P. gingivalis  has increasingly been recognized as a factor in the pathogenesis of AD. The present mini-review discusses possible mechanisms for the induction of neuroinflammation by  P. gingivalis  in AD, involving factors such as pro-inflammatory mediators, amyloid-beta, tau, microglia, cathepsin B, and protein kinase R. Inflammagens of  P. gingivalis  such as lipopolysaccharide and gingipains are also discussed.

Porphyromonas gingivalis-Induced Neuroinflammation in Alzheimer’s Disease