English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Astrocytes can protect neurons against oxidative stress and excitability-dependent disorders, such as epilepsy.  Valeriana officinalis  has been used as anticonvulsant and can exert an antioxidant effect, which may underlie its opposing action against the toxic effects of the pesticide rotenone. We investigated the  V. officinalis  / rotenone interaction in the cortical spreading depression (CSD), a phenomenon that depends upon brain excitability ( in vivo model) . In addition, we analyzed the protective action of  V. officinalis  against the cytotoxic effects of rotenone in cultures of rat C6 glioma cells ( in vitro  model). For the CSD study, Wistar rats received either  V. officinalis  (250 mg/kg/day via gavage for 15 days;  n  = 8) or 10 mg/kg/day rotenone via subcutaneous injections for 7 days ( n  = 7), or they received both substances ( n  = 5). Two control groups received either saline (vehicle for  V.  officinalis;  n  = 8) or 1% Tween-80 aqueous solution (vehicle for rotenone;  n  = 9). After treatment, CSD was recorded for 4 h. The rotenone- and  V. officinalis -treated groups presented, respectively, with lower (2.96 ± 0.14 mm/min), and higher CSD propagation velocity (3.81 ± 0.10 mm/min) when compared with the controls (Tween-80, 3.37 ± 0.06 mm/min and saline, 3.35 ± 0.08 mm/min;  p  < 0.05). The rotenone plus  V. officinalis -treated group displayed a CSD velocity (3.38 ± 0.07 mm/min) that was similar to controls. In line with these results,  in vitro  experiments on rat glioma C6 cells revealed a protective effect (MTT assay) of  V. officinalis  against rotenone-induced cytotoxicity. These results suggest the therapeutic potential of  V. officinalis  for treating neurological diseases involving redox imbalance and astrocyte dysfunction.

frontiers in neuroscience

Valeriana officinalis Counteracts Rotenone Effects on Spreading Depression in the Rat Brain in vivo and Protects Against Rotenone Cytotoxicity Toward Rat Glioma C6 Cells in vitro