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When two different images are presented to the two eyes dichoptically, observers usually experience a perceptual alternation between the two images. This phenomenon, known as binocular rivalry, has been used as a powerful tool to investigate mechanisms of visual awareness. It was also found that the rates of perceptual alternation are slower in patients with bipolar disorder than in healthy controls ( Pettigrew and Miller, 1998 ;  Miller et al., 2003 ). To investigate the broader clinical relevance of binocular rivalry in psychiatric disorders, we measured the perceptual alternation rates during rivalry in healthy controls ( n  = 39) and in patients with different types of psychiatric disorders, including bipolar disorder type I (BD,  n  = 28), obsessive–compulsive disorder (OCD,  n  = 22), major depression (MD,  n  = 50), schizophrenia (SCZ,  n  = 44), and first-degree relatives (FDRs) of SCZ patients ( n  = 32). Participants viewed competing red–green images on a computer monitor through red–green anaglyph glasses and pressed buttons to record their perceptual alternations. The distributions of the rivalry rates were well described by a lognormal function in all groups. Critically, the median rate of perceptual alternation was 0.27 Hz for BD patients, 0.26 Hz for the OCD patients, 0.25 Hz for the MD patients, and 0.23 Hz and 0.27 Hz for the SCZ patients and their FDRs, respectively. All of which were significantly slower than the rate of 0.41 Hz obtained for the healthy controls, suggesting there may be shared genotypes between these different disorders. While rivalry alternations were generally slower in different types of psychiatric disorders compared to healthy controls, adding variance of rivalry rates in the analysis helped to partially separate among the different patient groups. Our results suggest that the slowing of binocular rivalry is likely due to certain common factors among the patient groups, but more subtle differences between different patient groups could be revealed when additional properties of rivalry dynamics are considered.

Slower and Less Variable Binocular Rivalry Rates in Patients With Bipolar Disorder, OCD, Major Depression, and Schizophrenia