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The aim of this study was to explore changes in intracellular ATP generation and tight junction protein expression during the course of brain edema induced by subacute poisoning of 1,2-dichloroethane (1,2-DCE). Mice were exposed to 1.2 g/m 3  1,2-DCE for 3.5 h per day for 1, 2, or 3 days, namely group A, B, and C. Na + -K + -ATPase and Ca 2+ -ATPase activity, ATP and lactic acid content, intracellular free Ca 2+  concentration and ZO-1 and occludin expression in the brain were measured. Results of present study disclosed that Ca 2+ -ATPase activities in group B and C, and Na + /K + -ATPase activity in group C decreased, whereas intracellular free Ca 2+  concentrations in group B and C increased significantly compared with control. Moreover, ATP content decreased, whereas lactic acid content increased significantly in group C compared with control. On the other hand, expressions of ZO-1 and occludin at both the protein and gene levels in group B and C decreased significantly compared with control. In conclusion, findings from this study suggest that calcium overload and depressed expression of tight junction associated proteins, such as ZO-1 and occludin might play an important role in the early phase of brain edema formation induced by subacute poisoning of 1,2-DCE.

frontiers in neuroscience

Disruption of Intracellular ATP Generation and Tight Junction Protein Expression during the Course of Brain Edema Induced by Subacute Poisoning of 1,2-Dichloroethane