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In volumetric brain imaging analysis, volumes of brain structures are typically assumed to be proportional or linearly related to intracranial volume ( ICV ). However, evidence abounds that many brain structures have power law relationships with  ICV . To take this relationship into account in volumetric imaging analysis, we propose a power law based method—the power-proportion method—for  ICV  correction. The performance of the new method is demonstrated using data from the PREDICT-HD study.

The power-proportion method for intracranial volume correction in volumetric imaging analysis