English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Here we use computational modeling to gain new insights into the transformation of inputs in hippocampal field CA1. We considered input-output transformation in CA1 principal cells of the rat hippocampus, with activity synchronized by population gamma oscillations. Prior experiments have shown that such synchronization is especially strong for cells within one millimeter of each other. We therefore simulated a one-millimeter  patch  of CA1 with 23,500 principal cells. We used morphologically and biophysically detailed neuronal models, each with more than 1000 compartments and thousands of synaptic inputs. Inputs came from binary patterns of spiking neurons from field CA3 and entorhinal cortex (EC). On average, each presynaptic pattern initiated action potentials in the same number of CA1 principal cells in the patch. We considered pairs of similar and pairs of distinct patterns. In all the cases CA1 strongly separated input patterns. However, CA1 cells were considerably more sensitive to small alterations in EC patterns compared to CA3 patterns. Our results can be used for comparison of input-to-output transformations in normal and pathological hippocampal networks.

Input-to-output transformation in a model of the rat hippocampal CA1 network