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Disrupted-in-schizophrenia 1 ( DISC1 ) is a strong candidate susceptibility gene for a spectrum of neuropsychiatric diseases including schizophrenia, bipolar disorder and major depression, all of which are thought to result from interactions between gene mutations and environmental risk factors such as influenza, trauma and stress. Adolescence is a key period susceptible to stress and stress-related mental illnesses. In a previous study, we found that although  DISC1  L100P point mutation mice shows object recognition deficits, their sociability and social memory are relatively normal. Therefore, in this article, we investigated whether the interaction between adolescent stress and  DISC1  L100P point mutation affects adult social memory, and we explored the underlying mechanisms. We found that adolescent stress (isolation from 5 weeks to 8 weeks of age) specifically impaired social memory of adult  DISC1  L100P mice but not that of WT littermates, which could be rescued by administration of atypical antipsychotic drug clozapine. On the other hand, it did not induce anxiety or depression in adult mice. Adolescent isolation exacerbated adult neurogenesis deficits in the hippocampus of  DISC1  L100P mice, while it had no effect on WT mice. In addition, we found that adolescent isolation led to long lasting changes in synaptic transmission and plasticity in the hippocampal circuits, some of which are specific for  DISC1  L100P mice. In summary, we identified here the specific interaction between genetic mutation ( DISC1  L100P) and adolescence social stress that damages synaptic function and social memory in adult hippocampal circuits.   Highlights–  Adolescent isolation (from 5 weeks to 8 weeks of age) impairs adult social memory when combined with  DISC1  L100P point mutation.    –  Adolescent isolation exacerbates adult neurogenesis deficit in the hippocampus of L100P mice but has no similar effect on WT mice.    –  Adolescent isolation causes long lasting changes in synaptic transmission and plasticity of the hippocampal network in  DISC1  L100P mice.

Adolescent Isolation Interacts With DISC1 Point Mutation to Impair Adult Social Memory and Synaptic Functions in the Hippocampus