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The sodium leak channel NARROW ABDOMEN (NA)/ NALCN is an important component of circadian pacemaker neuronal output. In  Drosophila , rhythmic expression of the NA channel regulator  Nlf-1  in a subset of adult pacemaker neurons has been proposed to contribute to circadian regulation of channel localization or activity. Here we have restricted expression of  Drosophila  NA channel subunits or the  Nlf-1  regulator to either development or adulthood using the temperature-inducible  tubulin -GAL80 ts  system. Surprisingly, we find that developmental expression of endogenous channel subunits and  Nlf-1  is sufficient to promote robust rhythmic behavior in adults. Moreover, we find that channel complex proteins produced during development persist in the  Drosophila  head with little decay for at least 5–7 days in adults. In contrast, restricting either endogenous or transgenic gene expression to adult stages produces only limited amounts of the functional channel complex. These data indicate that much of the NA channel complex that functions in adult circadian neurons is normally produced during development, and that the channel complex is very stable in most neurons in the  Drosophila  brain. Based on these findings, we propose that circadian regulation of NA channel function in adult pacemaker neurons is mediated primarily by post-translational mechanisms that are independent of  Nlf-1.

The Narrow Abdomen Ion Channel Complex Is Highly Stable and Persists from Development into Adult Stages to Promote Behavioral Rhythmicity