English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Professional deep sea divers experience motor and cognitive impairment, known as High Pressure Neurological Syndrome (HPNS), when exposed to pressures of 100 msw (1.1 MPa) and above, considered to be the result of synaptic transmission alteration. Previous studies have indicated modulation of presynaptic Ca 2+  currents at high pressure. We directly measured for the first time pressure effects on the currents of voltage dependent Ca 2+  channels (VDCCs) expressed in  Xenopus  oocytes. Pressure selectivity augmented the current in Ca V 1.2 and depressed it in Ca V 3.2 channels. Pressure application also affected the channels' kinetics, such as Ʈ Rise , Ʈ Decay . Pressure modulation of VDCCs seems to play an important role in generation of HPNS signs and symptoms.

Selective modulation of cellular voltage-dependent calcium channels by hyperbaric pressureâ€”a suggested HPNS partial mechanism