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Spinal cord injury (SCI) is a debilitating neuropathology with no effective treatment. Magnetic resonance imaging (MRI) technology is the only method used to assess the impact of an injury on the structure and function of the human spinal cord. Moreover, in pre-clinical SCI research, MRI is a non-invasive method with great translational potential since it provides relevant longitudinal assessment of anatomical and structural alterations induced by an injury. It is only recently that MRI techniques have been effectively used for the follow-up of SCI in rodents. However, the vast majority of these studies have been carried out on rats and when conducted in mice, the contusion injury model was predominantly chosen. Due to the remarkable potential of transgenic mice for studying the pathophysiology of SCI, we examined the use of both  in  and  ex vivo   1 H-MRI (9.4 T) in two severities of the mouse SCI (hemisection and over-hemisection) and documented their correlation with histological assessments. We demonstrated that a clear distinction between the two injury severities is possible using  in  and  ex vivo   1 H-MRI and that  ex vivo  MR images closely correlate with histology. Moreover, tissue modifications at a remote location from the lesion epicenter were identified by conventional  ex vivo  MRI analysis. Therefore,  in vivo  MRI has the potential to accurately identify in mice the progression of tissue alterations induced by SCI and is successfully implemented by  ex vivo  MRI examination. This combination of  in  and  ex vivo  MRI follow-up associated with histopathological assessment provides a valuable approach for further studies intended to evaluate therapeutic strategies on SCI.

Correlation of in vivo and ex vivo1H-MRI with histology in two severities of mouse spinal cord injury