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Background  Subjective cognitive decline (SCD) was considered to be the preclinical stage of Alzheimer’s disease (AD). However, less is known about the altered rich-club organizations of the morphological networks in individuals with SCD.    Methods  This study included 53 individuals with SCD and 54 well-matched healthy controls (HC) from the Alzheimer’s disease Neuroimaging Initiative (ADNI) database. Individual-level brain morphological networks were constructed by estimating the Jensen-Shannon distance-based similarity in the distribution of regional gray matter volume. Rich-club properties were then detected, followed by statistical comparison.    Results  The characteristic rich-club organization of morphological networks (normalized rich-club coefficients &amp;gt; 1) was observed for both the SCD and HC groups under a range of thresholds. The SCD group showed a reduced normalized rich-club coefficient compared with the HC group. The SCD group exhibited the decreased strength and degree of rich-club connections than the HC group (strength: HC = 79.93, SCD = 74.37,  p  = 0.028; degree: HC = 85.28, SCD = 79.34,  p  = 0.027). Interestingly, the SCD group showed an increased strength of local connections than the HC group (strength: HC = 1982.16, SCD = 2003.38,  p  = 0.036).    Conclusion  Rich-club organization disturbances of morphological networks in individuals with SCD reveal a distinct pattern between the rich-club and peripheral regions. This altered rich-club organization pattern provides novel insights into the underlying mechanism of SCD and could be used to investigate prevention strategies at the preclinical stage of AD.

Rich-Club Organization Disturbances of the Individual Morphological Network in Subjective Cognitive Decline