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Study Objectives:  The aim of the study was to investigate the relationship between 22 single nucleotide polymorphisms (SNPs) and Parkinson’s disease (PD) in the Chinese population.   Methods:  A total of 250 PD patients and 240 healthy controls were recruited. The SNaPshot technique and the polymer chain reaction were used to detect 22 SNPs.   Results:  rs8005172 of  GALC , rs9468199 of  ZNF184  and rs34043159 of  IL1R2 , were associated with PD (rs8005172:  p  = 0.009, OR = 0.69, allele model,  p  = 0.010, additive model,  p  = 0.015, OR = 2.17, dominant model;  p  = 0.020, OR = 2.11, dominant model after adjustment;  p  = 0.036, OR = 1.47, recessive model after adjustment; rs9468199:  p  = 0.008, OR = 1.52, allele model,  p  = 0.008, additive model,  p  = 0.007, OR = 0.22, recessive model,  p  = 0.005, OR = 0.20, recessive model after adjustment; rs34043159:  p  = 0.034, OR = 1.31, allele model,  p  = 0.036, additive model).   Conclusion:  Our study revealed that  GALC ,  ZNF184 , and  IL1R2  were associated with PD in the southern Chinese population.  GALC  was also associated with LOPD.  ELOVL7  and  ZNF184  were associated with EOPD. In addition, trends of association to PD, between  SATB1 ,  NMD3 , and  FGF20 , were also found.   Statement of Significance:  Genetic play an important role in the pathogenesis factors of Parkinson’s disease (PD). We found that  GALC ,  ZNF184 , and  IL1R2  were associated with PD.  GALC  was also associated with late onset of PD, while  ELOVL7  and  ZNF184  were associated with early onset PD. This study is the first to find an association between  GALC ,  ZNF184 , and rs2280104 with PD.

Association of GALC, ZNF184, IL1R2 and ELOVL7 With Parkinson’s Disease in Southern Chinese