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Objective:  To determine whether single nucleotide polymorphisms (SNPs) of the cholinergic system and quantitative parameters of postural control are associated in healthy older adults. This is a cross-sectional analysis from the TREND study.   Methods:  All participants performed a static postural control task for 30 s on a foam pad in semitandem stance and eyes closed. We analyzed mean power frequency (MPF), area, acceleration, jerk, and velocity from a mobile sensor worn at the lower back using a validated algorithm. Genotypes of four SNPs in genes involved in the cholinergic system ( SLC5A7, CHAT, BCHE, CHRNA4 ) were extracted from the NeuroX chip. All participants present a normal neurological examination and a Minimental state examination score >24.   Results:  Four hundred and seventy seven participants were included. Mean age was 69 years, 41% were female. One SNP of the cholinergic pathway was significantly associated with a quantitative postural control parameter. The minor allele of rs6542746 in  SLC5A7  was associated with lower MPF (4.04 vs. 4.22 Hz;  p  = 3.91 × 10 -4 ). Moreover, the following associations showed trends toward significance: minor allele of rs6542746 in  SLC5A7  with higher anteroposterior acceleration (318 vs. 287 mG;  p  = 0.005), and minor allele of rs3810950 in  CHAT  with higher mediolateral acceleration [1.77 vs. 1.65 log(mG);  p  = 0.03] and velocity [1.83 vs. 1.74 log(mm/s);  p  = 0.019]. Intraindividual occurrence of rs6542746 and rs3810950 minor alleles was dose-dependently related with lower MPF ( p  = 0.004).   Conclusion:  This observational study suggests an influence of SNPs of the cholinergic pathway on postural control in older adults.

Cholinergic Pathway SNPs and Postural Control in 477 Older Adults