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Following two decades of research after the first clinical reports that a sleep disturbance can precede signs and motor symptoms of Parkinson's disease (PD) (Schenck et al., 1996), studies examining sleep at the cellular and systems-wide level in PD-diagnosed and preclinical PD patients have lead to the belief among sleep researchers that disturbed sleep occurs long before PD diagnosis and could be a predictor of the disease [For example, see (Postuma et al., 2009a,b; Hansen et al., 2013)]. More excitingly, these studies have led to the tantalizing conclusion that aggressive treatment of sleeping disorders could actually delay progression of PD. However, while clinicians fully expect presence of sleeping disorders in their PD-diagnosed patients and manage these complaints (Jahan et al., 2009; Diederich and McIntyre, 2012; Klingelhoefer et al., 2014), the possibility of exploitation of the link between PD and sleeping disorders for pre-clinical PD diagnosis or treatment approaches designed to delay motor symptoms of PD has not gone far outside the sleep research field. Despite the fact that there is a significant literature comprised of human epidemiological and post-mortem studies, as well as animal studies, which have correlated varying manifestations of sleep disorders or changes in neural areas controlling sleep, as preceding or simultaneous with PD [For example, see (Arnulf et al., 2002, 2008; Korczyn, 2006; De Cock et al., 2008; Stavitsky and Cronin-Golomb, 2011)], clinicians fail to strongly consider that a patient presenting with a sleeping disorder has a higher risk of later life development of PD and that, therefore, these patients should be carefully monitored for eventual onset of the classic signs of neurodegenerative diseases such as PD. Nor is it standard practice to suggest prophylactic approaches in these patients to curb onset of PD.

Treatment of sleeping disorders should be considered in clinical management of Parkinson's disease