English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Based on the premise that oxidative stress plays an important role in severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection, we speculated that variations in the antioxidant activities of different members of the glutathione S-transferase family of enzymes might modulate individual susceptibility towards development of clinical manifestations in COVID-19. The distribution of polymorphisms in cytosolic glutathione S-transferases  GSTA1 ,  GSTM1 ,  GSTM3 ,  GSTP1  ( rs1695  and  rs1138272 ), and  GSTT1  were assessed in 207 COVID-19 patients and 252 matched healthy individuals, emphasizing their individual and cumulative effect in disease development and severity.  GST  polymorphisms were determined by appropriate PCR methods. Among six  GST  polymorphisms analyzed in this study,  GSTP1  rs1695 and  GSTM3  were found to be associated with COVID-19. Indeed, the data obtained showed that individuals carrying variant  GSTP1 - Val  allele exhibit lower odds of COVID-19 development ( p  = 0.002), contrary to carriers of variant  GSTM3-CC  genotype which have higher odds for COVID-19 ( p  = 0.024). Moreover, combined  GSTP1  ( rs1138272  and  rs1695 ) and  GSTM3  genotype exhibited cumulative risk regarding both COVID-19 occurrence and COVID-19 severity ( p  = 0.001 and  p  = 0.025, respectively). Further studies are needed to clarify the exact roles of specific glutathione S-transferases once the SARS-CoV-2 infection is initiated in the host cell.

GSTP1 and GSTM3 Variant Alleles Affect Susceptibility and Severity of COVID-19