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The alternative streptococcal σ-factor and master competence regulator, σ X , stimulates transcription from competence promoters,  in vitro.  As the only known alternative σ-factor in streptococci, σ X  expression is tightly controlled in each species and has a specific physiological role. Pneumococcal transformation also requires the DNA binding activity of ComW, a known σ X  activator and stabilizer. Mutations to the housekeeping σ factor, σ A , partially alleviate the ComW requirement, suggesting that ComW is a key player in the σ factor swap during the pneumococcal competence response. However, there is no evidence of a direct ComW – RNA polymerase interaction. Furthermore, if and how ComW functions directly at combox promoters is still unknown. Here we report that a DNA-binding ComW variant, ComΔ6, can stimulate transcription from σ X  promoters  in vitro .

ComWΔ6 Stimulates Transcription of Pneumococcal Competence Genes in vitro