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Enterococcus faecalis  is a Gram-positive opportunistic pathogen that causes nosocomial infections in humans. Due to the growing threat of antibiotic resistance of  E. faecalis , bacteriophage therapy is a promising option for treating of  E. faecalis  infection. Here, we characterized a lytic  E. faecalis  bacteriophage vB_EfaS_efap05-1 with a dsDNA genome of 56,563 bp. Phage vB_EfaS_efap05-1 had a prolate head and a tail, and belongs to Saphexavirus which is a member of  Siphoviridae . Efap05-1 uses either surface polysaccharide or membrane protein ComEA as the receptor because the mutation of both genes ( ComEA  and UDP-glucose 4-epimerase  galE ) prevents phage adsorption and leads to phage resistance, and complementation of  ComEA  or  galE  could recover its phage sensitivity. Our results provided a comprehensive analysis of a new  E. faecalis  phage and suggest efap05-1 as a potential antimicrobial agent.

Enterococcus faecalis Bacteriophage vB_EfaS_efap05-1 Targets the Surface Polysaccharide and ComEA Protein as the Receptors