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Campylobacter jejuni  is a major bacterial cause of human diarrheal diseases worldwide. Despite its sensitivity to environmental stresses,  C. jejuni  ubiquitously distributes throughout poultry production chains. Biofilm formation mediated by quorum sensing is suggested to be critical to the survival of  C. jejuni  in agroecosystem.  C. jejuni  possesses LuxS, the enzyme involved in the production of autoinducer-2 (AI-2) signaling molecules. In this study, two fatty acids, namely decanoic acid and lauric acid, were identified to be effective in inhibiting AI-2 activity of  C. jejuni . Both decanoic acid and lauric acid at 100 ppm inhibited ∼90% AI-2 activity ( P  &amp;lt; 0.05) of  C. jejuni  without bacterial inactivation. The biofilm biomass of two  C. jejuni  strains was reduced by 10–50% ( P  &amp;lt; 0.05) after treatment by both fatty acids, while increased biofilm formation was observed for one  C. jejuni  strain. In addition, both fatty acids effectively reduced the motility of all tested  C. jejuni  strains. These findings can aid in developing alternative  C. jejuni  control strategies in agri-food and clinical settings.

Inhibition of AI-2 Quorum Sensing and Biofilm Formation in Campylobacter jejuni by Decanoic and Lauric Acids