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Infections due to  Staphylococcus argenteus  have been increasingly reported worldwide and the microbe cannot be distinguished from  Staphylococcus aureus  by standard methods. Its complement of virulence determinants and antibiotic resistance genes remain unclear, and how far these are distinct from those produced by  S. aureus  remains undetermined. In order to address these uncertainties, we have collected 132 publicly available sequences from fourteen different countries, including the United Kingdom, between 2005 and 2018 to study the global genetic structure of the population. We have compared the genomes for antibiotic resistance genes, virulence determinants and mobile genetic elements such as phages, pathogenicity islands and presence of plasmid groups between different clades. 20% ( n  = 26) isolates were methicillin resistant harboring a  mec A gene and 88% were penicillin resistant, harboring the  blaZ  gene. ST2250 was identified as the most frequent strain, but ST1223, which was the second largest group, contained a marginally larger number of virulence genes compared to the other STs. Novel  S. argenteus  pathogenicity islands were identified in our isolates harboring  tsst-1, seb, sec3, ear, selk, selq  toxin genes, as well as chromosomal clusters of enterotoxin and superantigen-like genes. Strain-specific type I modification systems were widespread which would limit interstrain transfer of genetic material. In addition, ST2250 possessed a CRISPR/Cas system, lacking in most other STs.  S. argenteus  possesses important genetic differences from  S. aureus , as well as between different STs, with the potential to produce distinct clinical manifestations.

Genomic Analysis of Global Staphylococcus argenteus Strains Reveals Distinct Lineages With Differing Virulence and Antibiotic Resistance Gene Content