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Long non-coding RNAs are involved in many infectious diseases. Our previous studies showed that  lncRNA-ENST421645  expression is increased in T lymphocytes of neurosyphilis patients compared to healthy controls. However, whether  lncRNA-ENST421645  has biological functions remains unclear. The current study was undertaken to understand the mechanism of  lncRNA-ENST421645  in T lymphocyte function in neurosyphilis patients. The  lncRNA-ENST421645  pull-down assay showed that  lncRNA-ENST421645  acted on the acetylase NAT10. The chromatin immunoprecipitation (ChIP)-PCR results showed that  lncRNA-ENST421645  promoted the acetylation of histone H3K27 adjacent to the Kank1 promoter, thereby promoting Kank1 protein expression. Kank1 promotes 14-3-3 protein expression, inhibits NF-kB activation, inhibits IFN-γ secretion by T lymphocytes, and promotes T lymphocyte apoptosis. Taken together, our findings suggest a novel mechanism that  LncRNA-ENST421645  upregulates  Kank1  to inhibit IFN-γ expression and promote T cell apoptosis in neurosyphilis.

LncRNA-ENST00000421645 Upregulates Kank1 to Inhibit IFN-γ Expression and Promote T Cell Apoptosis in Neurosyphilis